Endocrine Abstracts

Introduction: Brittle hypertyroidism is a term used for the clinical situation characterized by hypo-hyperthyroidism with antithyroid drugs, despite good compliance and follow-up. Here, we presented five patients suggested to have Brittle Graves.Case-1: Thyrotoxicosis was observed in a 57-year-old female patient and Graves was diagnosed after laboratory and imaging examinations 25 months after initiation of propylthiouracil 50 mg/day, she developed hypot...

Aim: Lithium bicarbonate is a drug used in the initial treatment of bipolar disorders. Lithium is an element of alcali metal group and besides being a causative agent for goiter and hypothyroidism primarily, it has also some antithyroid effects. Rarely, lithium may cause hyperthyroidism secondary to thyroiditis or probably autoimmune mechanisms. The association between lithium and thyroid cancer is very little known subject. In this case series, we presented differentiated thy...

Introduction: Parathyroid cancer (PC) is rare accounting for <1% of all presentations. Tumors that demonstrate these atypical features and do not fulfill criteria for carcinoma can be classified as atypical adenomas (APA). Herein we aimed to evaluate the clinical and biochemical features of the patients with an atypical parathyroid adenoma or carcinoma and compare it with benign parathyroid adenomas.Method: Twenty-eight patients who were operated for...

Introduction: Acromegaly patients are known to have an increased risk of malignancies. This may be as a result of the effect of insulin-like growth factor I (IGF-I) on cellular proliferation and apoptosis inhibition. Although there are various reports related with hematological malignancies in children who treated with growth hormone (GH), few data are available about hematological malignancies in acromegaly patients. Here, we report a patient with acromegaly who has been deve...

Introduction: Rathke’s cleft cyst is one of the pituitary non-adenomatous tumors that found in about 20% of pituitary glands at autopsy. Symptomatic Rathke’s cleft cysts are rarely, but these cysts can cause serious medical problems associated with compression of the pituitary gland, pituitary stalk, optic nerve or hypothalamus. Here, we report a rare case of 73 years old man with sudden onset headache due to Rathke’s cleft cyst present with symptoms and radiolo...

Introduction: Klinefelter syndrome is known as the set of symptoms that result from two or more X chromosomes in males. There is no known association of this syndrome with GH hypersecretion. The most remarkable symptom is gigantism and it can also be observed in androgen deficient states as such as the Klinefelter syndrome and some more genetic syndromes such as the Sotos syndrome, the Marfan syndrome, the homocystinuria, and the fragile X-syndrome. Herein we presente...

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive diseases characterized by enzyme deficiencies in cortisol secretion. The most common form is 21-alpha hydroxylase deficiency. Here, we report a patient with undertreated CAH and bilateral large adrenal masses.Case report: 34 years old male patient diagnosed with CAH and testicular anorchia at the age of 7 admitted to our clinic for general weakness. Hydrocortisone treatm...

Introduction: Ectopic and atypically localized parathyroid adenomas such as in the anterior mediastinum, paraesophageal or retrotracheal position, although rare, can be seen in clinical practice. Ultrasound (US) which is a frequently used and one of the best conventional imaging modality sometimes fails to identify the lesion especially in atypically localized adenomas. Endoscopic US (EUS) is a new technique that can be used for localization of parathyroid lesions. We reported...

Introduction: Parathyroid lipoadenoma (PLA) is a rarely seen, benign variant of parathyroid adenoma (PA). However, PA usually consists of uniform, polygonal chief cells with a few nests of oxyphil cells, PLA consists of similar histologic features, but with an abundance of fat cells. Additionally, PLA may be functional with the secretion of parathyroid hormone (PTH) or non-functional. Here, we present a case of atypical PLA presented with severe hypercalcemia and skeletal defo...

Introduction: Primary hyperparathyroidism (pHPT) during pregnancy is rare and associated with increased morbidity for both mother and fetus. Maternal complications of pHPT include nepfhrolithiasis, pancreatitis, cardiac arrhytmias, hypertension, nausea and vomiting. pHPT is caused by a solitary adenoma in 85–90% of patients, and the curative treatment is parathyroidectomy. Here, we presented two women who have diagnosed pHPT and operated without complications in pregnancy...